人腺病毒工程化应用研究进展

Progress in engineering application of human adenovirus

摘要:

人腺病毒流行广泛，感染常诱发呼吸道疾病、流行性结膜炎等疾病。腺病毒是研究较为深入的一类病原体，并且作为病毒载体已广泛应用，也是基因治疗最常用的病毒载体，尤其在肿瘤基因治疗和病毒溶瘤方面具有较大的研究价值和临床应用潜力。文中对腺病毒的生物学特性以及应用范围等方面进行综述，以期为腺病毒的工程化与临床应用提供参考。

Abstract:

Human adenoviruses are widespread causative agent that induces respiratory diseases, epidemic keratoconjunctivitis and other related diseases. Adenoviruses are commonly used in experimental and clinical areas. It is one of the most commonly used virus vectors in gene therapy, and it has attracted a lot of attention and has a high research potential in tumor gene therapy and virus oncolytic. Here, we summarize the biological characteristics, epidemiology and current application of adenovirus, in order to provide reference for engineering application of adenovirus.