ABC转运蛋白及其在合成生物学中的应用

ABC transporter and its application in synthetic biology

摘要:

ABC转运蛋白 (ATP-binding cassette transporter，ABC transporter) 作为一种超大膜转运蛋白家族，在大多数生物体中发挥着重要作用。文中从结构特征、转运机制以及生理功能等方面论述了ABC转运蛋白的研究进展，进而着重综述了近些年来ABC转运蛋白在合成生物学领域中的应用，并为今后进一步的研究提出了展望，希望为扩展其应用提供指导。

Abstract:

As an ancient and huge family of membrane proteins, ATP-binding cassette transporter (ABC transporter) plays an important physiological role in most organisms. Herein, we introduce the research progress in ABC transporters on the aspects of structural characteristic, transport mechanism and physiological functions. We also focus on the application of ABC transporters in the field of synthetic biology in recent years. Finally, we propose future research needs.