治疗性抗体药物差异化研发策略

Differential discovery strategies of therapeutic antibody drugs

摘要:

治疗性抗体药物在临床上取得了巨大的成功，然而在有效性和安全性方面还有待提高，同时药物靶点过于集中造成了重复开发、资源浪费等问题。因此，医药企业在研发抗体药物时需要探寻差异化的研发策略，从而在激烈的市场竞争中生存和发展。文中从药物的来源、结构形式、靶点选择、药物作用机制和差异化药物特性等方面探讨了治疗性抗体药物的差异化研发策略。

Abstract:

Therapeutic antibody drugs have achieved great success in clinical practice. However, their efficacy and safety still need to be improved. At the same time, excessive concentration of drug targets will cause problems such as repeated development and waste of resources. Therefore, pharmaceutical companies need to explore differentiated discovery strategies when researching antibody drugs in order to survive and develop in the fierce market competition. In this paper, the differential development strategy of therapeutic antibody drugs is discussed from the aspects of drug sources and formats, drug target selection, drug mechanism and differential drug characteristics.