人乳寡糖2’-FL和3-FL的生物制备研究进展

Recent advances in the bio-production of human milk oligosaccharides 2’-FL and 3-FL

摘要:

人乳寡糖 (Human milk oligosaccharides，HMO) 是母乳中重要的免疫活性成分，对婴幼儿健康起到显著促进作用。2’-岩藻糖基乳糖 (2’-FL) 是HMO的主要组分，极具应用价值，3-岩藻糖基乳糖 (3-FL) 与2’-FL的合成途径相似，两者的研究具有相互借鉴意义，近年来针对它们的研究取得了较多进展。以微生物细胞工厂为核心理念的新型生物合成途径有望将2’-FL和3-FL产业化，未来将对乳制品行业产生重要的影响。文中综述了生物技术制备2’-FL和3-FL的最新研究进展，并对未来发展趋势进行了展望。

Abstract:

Human milk oligosaccharides (HMO) are important immunoactive components found in breast milk. Scientific research proves that HMOs are significantly beneficial for infant health. 2’-fucosyllactose (2’-FL) is the major component of HMO, which obtained growing attentions from food industry. Besides, 3-fucosyllactose (3-FL) is another important fucosyllactose and it has a similar synthetic route comparing to 2’-FL. Thus, research of the two HMO components has interactive effects for each other. Recently, numerous publications are available for 2’-FL and 3-FL. The microbial cell factory is able to massively produce fucosyllactose via an efficient way, which will show considerable influences in dairy industry. In this paper, we review recent studies on 2’-FL and 3-FL, and discuss their prospects according to published literature and patents.