代谢工程30年专刊序言 (2021)

Preface for special issue on the 30th anniversary of metabolic engineering (2021)

摘要:

代谢工程利用重组DNA技术、合成生物学、基因组编辑来改变生物体的细胞网络，包括代谢、基因调控和信号网络等。它可以实现加强包括化学品、燃料、化学原料药和其他生物技术产品等代谢物生产的目标，提升生物制造能力与效率。为了梳理和凝练代谢工程30年来的发展状况，《生物工程学报》特组织出版专刊，从代谢工程总体发展、共性技术以及以什么宿主和做什么产品等4个方面展现该领域的发展动态和趋势，并为代谢工程领域的进一步发展提出建设性的意见与展望。

Abstract:

Metabolic engineering is the use of recombinant DNA technology, synthetic biology and genome editing to modify the cellular networks including metabolic, gene regulatory, and signaling networks of an organism. It can achieve the desirable goals such as enhanced production of metabolites, and improve the capability of biomanufacturing pharmaceuticals, biofuels and biochemicals as well as other biotechnology products. In order to comprehend the status of metabolic engineering in past 30 years, we published this special issue to review the progress and trends of metabolic engineering from the four aspects of overall development, key technologies, host engineering and product engineering, respectively, for laying the foundation for the further development of metabolic engineering.