丝状真菌代谢工程研究进展

Advances in metabolic engineering of filamentous fungi

摘要:

丝状真菌 (Filamentous fungi)作为重要的工业发酵微生物，在有机酸、蛋白质及次级代谢产物等关键生物基产品生产方面发挥着重要作用。自20世纪90 年代代谢工程理念提出以来，尤其是代谢工程使能技术的创新及发展，极大地促进了丝状真菌细胞工厂的构建及其在工业发酵领域的应用。文中将系统介绍近年来丝状真菌代谢工程技术的发展，及其在生物基化学品细胞工厂构建中的应用，最后讨论丝状真菌代谢工程中关键问题并展望其未来发展。

Abstract:

Filamentous fungi are important industrial microorganisms that play important roles in the production of bio-based products such as organic acids, proteins and secondary metabolites. The development of metabolic engineering and its enabling techniques have greatly promoted the design, construction and application of filamentous fungal cell factories. This article systematically reviews the development of filamentous fungal cell factories constructed through metabolic engineering, and discusses the challenges and future perspectives for systems metabolic engineering of filamentous fungi.