超分子多肽自组装在生物医学中的应用

Application of supramolecular peptide self-assembly in biomedicine

摘要:

近年来，自组装多肽纳米技术因其可形成规则有序的结构、具有多样的功能而备受关注。研究发现自组装多肽能在特定的条件下形成具有确定结构的聚集体，这种聚集体具备生物相容性好、稳定性高等优点，表现出不同于单体多肽分子的特性和优势，因此其在药物传递、组织工程、抗菌等领域具有良好的应用前景。文中介绍了自组装多肽形成的分子机理、类型、影响因素，综述了自组装多肽形成的纤维肽基水凝胶与自组装抗菌肽的最新进展，并提出目前多肽自组装技术所存在的问题及展望。

Abstract:

In recent years, peptide self-assembly has received much attention because of its ability to form regular and ordered structures with diverse functions. Self-assembled peptides can form aggregates with defined structures under specific conditions. They show different characteristics and advantages (e.g., good biocompatibility and high stability) compared with monomeric peptides, which form the basis for potential application in the fields of drug delivery, tissue engineering, and antiseptics. In this paper, the molecular mechanisms, types and influencing factors of forming self-assembled peptides were reviewed, followed by introducing the latest advances on fibrous peptide hydrogels and self-assembled antimicrobial peptides. Furthermore, the challenges and perspectives for peptide self-assembly technology were discussed.