乳酸菌作为药物分子粘膜投递载体的研究进展

Advances in the use of lactic acid bacteria as mucosal delivery vectors of therapeutic molecules

摘要:

乳酸菌是被公认为安全的食品级微生物，广泛地应用于食品生产、保存以及作为益生菌促进人类健康。鉴于发展有效的投递药物分子策略的需要，乳酸菌成为了极有吸引力的用于口服、鼻饲及阴道进行粘膜投递药物分子的活载体。用乳酸菌作为药物分子的投递载体，安全性好，且可直接合成并投递目标蛋白，显著降低药物生产成本。到目前为止，乳酸菌作为粘膜投递载体，已成功地向粘膜组织投递了一系列功能蛋白用以治疗多种疾病。文中综述了近20年的数据，重点聚焦乳酸菌作为药物分子投递载体的发展和应用，为今后乳酸菌作为活载体的临床研究提供一定参考。

Abstract:

Lactic acid bacteria (LAB) are generally recognized as safe food-grade microorganisms and are widely used in food production, preservation, and as probiotics to promote human health. Given the need to develop effective drug delivery strategies, LAB have become attractive live vehicles for the oral, intranasal and vaginal delivery of therapeutic molecules. Being live and safe organisms, LAB are able to directly produce and deliver target proteins for therapeutic purpose, which remarkably reduces the cost for drug production. To date, LAB have been used to deliver a variety of functional proteins to mucosal tissues for the treatment of various diseases. This review summarized the development and application of LAB as mucosal delivery vectors in the last 20 years to provide references for future clinical research.