长链非编码RNA介导Wnt/β-catenin信号通路调控骨代谢的研究进展

Long non-coding RNA regulates bone metabolism via Wnt/β-catenin signaling pathway

摘要:

骨代谢的平衡取决于骨形成及骨吸收之间的动态平衡，Wnt/β-catenin信号通路能够广泛参与骨吸收及骨形成的调控，在维持骨代谢平衡中发挥着重要作用。近年来有研究表明，长链非编码RNA (Long non-coding RNA, lncRNA) 也广泛参与骨代谢各阶段的调节，还能通过Wnt/β-catenin信号通路参与骨代谢平衡的调控。目前关于lncRNA介导Wnt/β-catenin信号通路调控骨代谢的综述报道较为鲜见。鉴于此，文中主要以Wnt/β-catenin信号通路为切入点，概述lncRNA在骨代谢中的调控作用，发现lncRNA能够通过靶向作用于miRNA间接调控Wnt/β-catenin信号通路，也能通过Wnt/β-catenin信号通路上的关键因子直接激活或抑制Wnt/β-catenin信号通路，进而发挥其对骨代谢的调控作用，这些发现为lncRNA调控骨代谢作用机制的研究提供了新的思路和方向。

关键词:长链非编码RNA，Wnt，β-连环蛋白，骨代谢

Abstract:

The balance of bone metabolism depends on the dynamic balance between bone formation and bone resorption. Wnt/β-catenin signaling pathway is involved in the regulation of bone resorption and bone formation, and plays an important role in maintaining the balance of bone metabolism. Recently, long non-coding RNA (lncRNA) is shown to play an essential role in different process of bone metabolism. LncRNA can also regulate the balance of bone metabolism via Wnt/β-catenin signaling pathway. Few studies report that lncRNA regulates bone metabolism via Wnt/β-catenin signaling pathway. Therefore, we summarize here the role of lncRNA in bone metabolism from the perspective of Wnt/β-catenin signaling pathway. LncRNA indirectly regulates Wnt/β-catenin signaling pathway by targeting miRNAs as well as activating or inhibiting Wnt/β-catenin signaling pathway via targeting the key molecules of Wnt/β-catenin signaling pathway, thus to regulate bone metabolism. These findings provide new ideas and directions for the study of the mechanism whereby lncRNA regulates bone metabolism.

Key words:lncRNA, Wnt, β-catenin, bone metabolism