酶制剂清除食源性致病菌生物被膜的研究进展

Enzyme-based targeted disintegration of biofilms formed by food-borne pathogens: a review

摘要:

食源性致病菌对人类健康与公众安全造成了极大的危害，形成生物被膜加剧了它们的致病与耐药风险。酶具有高度专一性，可靶向作用于生物被膜中的特殊物质，从而清除食源性致病菌的生物被膜，具有重要的科研价值和广泛的应用前景。因此，文中系统地综述了相关酶制剂清除食源性致病菌生物被膜的研究进展。根据酶制剂的不同作用靶点，着重介绍了群体感应抑制酶、环二鸟苷酸代谢酶、胞外基质水解酶等酶制剂的研究现状。文中还针对抗生物被膜酶制剂的未来研究方向进行了展望，旨在为食源性致病菌生物被膜的有效控制提供新的技术与策略。

Abstract:

Food-borne pathogens pose great risks to human health and public safety, and the formation of biofilm exacerbates their pathogenicity and antimicrobial resistance. Enzymes can target special substances in the biofilm to disintegrate the biofilm of food-borne pathogens, which has great potential for applications. This review summarized the progress of using enzymes to disintegrate the biofilms of food-borne pathogens, highlighting quorum-quenching enzymes, C-di-GMP metabolic enzymes, as well as extracellular matrix hydrolases. Finally, challenges and perspectives on developing enzymes into effective products for disintegrating the biofilms of food-borne pathogens were discussed.