NR2F6在肿瘤中的研究进展

The role of nuclear receptor transcription factor NR2F6 in tumor

摘要:

核受体亚族2，F组第6号成员NR2F6 (Nuclear receptor subfamily 2，group F，member 6) 是孤核受体中的一员，在人体主要组织、器官中均有表达，对多种生物学功能和基因表达调控起着重要的作用。近年来其与肿瘤发生发展的关系受到广泛关注，研究表明，NR2F6在多种肿瘤中表达均有上调，与多种癌症具有明显的相关性；此外最新研究表明，NR2F6在肿瘤免疫方面同样具有重要功能，有望成为新型免疫调节靶点。文中就近年来国内外有关NR2F6的功能及其在肿瘤中的相关研究进行综述，以期为肿瘤治疗提供新思路。

Abstract:

Nuclear receptor subfamily 2, group F, member 6 (NR2F6) is a member of orphan nuclear receptors, which is expressed in major tissues and organs of the human body, and plays an important role in the regulation of various biological functions and gene expressions. Recent studies have shown that the expression of NR2F6 was up-regulated in a variety of malignant tumors and showed significant correlations with cancer progression. These findings triggered the widespread interest in understanding the relationship between NR2F6 and cancer development and progression. In addition, the latest studies have underscored that NR2F6 was involved in enhancing antitumor immune responses that could serve as a potential target for immune regulation. This review summarizes the biological functions of NR2F6 and its role in tumors, with the aim to provide new insights into effective cancer therapies.