RPD3家族成员调控植物发育及环境应答的分子机制

Molecular mechanisms of RPD3 family members in regulating plant development and environmental responses

摘要:

赖氨酸乙酰化是翻译后修饰的主要类型之一，在调节基因表达和蛋白质功能中起关键作用。组蛋白去乙酰化酶 (Histone deacetylases，HDACs) 负责从组蛋白和非组蛋白的赖氨酸中去除乙酰基。RPD3家族是研究最广的HDACs，文中对拟南芥RPD3家族在多个生长发育过程中的调控机制进行了综述，为深入研究RPD3家族成员调控植物发育的机制提供参考，也为探索HDACs其他家族成员的功能提供较为清晰的研究思路。

Abstract:

Lysine acetylation is one of the major post-translational modifications and plays critical roles in regulating gene expression and protein function. Histone deacetylases (HDACs) are responsible for the removal of acetyl groups from the lysines of both histone and non-histone proteins. The RPD3 family is the most widely studied HDACs. This article summarizes the regulatory mechanisms of Arabidopsis RPD3 family in several growth and development processes, which provide a reference for studying the mechanisms of RPD3 family members in regulating plant development. Moreover, this review may provide ideas and clues for exploring the functions of other members of HDACs family.