大环内酯类抗生素微生物降解的研究进展

Advances in biodegradation of macrolide antibiotics

摘要:

大环内酯类抗生素是一类以大环内酯为母核的广谱抗生素。近些年，由于人们对其不规范的生产和使用，抗生素污染成为了重要的环境问题。大量研究表明，微生物降解是现阶段处理抗生素污染的最理想方法。为进一步推动大环内酯类抗生素生物降解的研究，文中概述了大环内酯类抗生素的环境污染现状、微生物降解菌株、降解酶、降解途径和降解大环内酯类抗生素的微生物处理方法，并对大环内酯类抗生素生物降解亟待解决的瓶颈问题进行了讨论，以期为微生物降解后续研究提供参考。

Abstract:

Macrolide antibiotics are a class of broad-spectrum antibiotics with the macrolide as core nucleus. Recently, antibiotic pollution has become an important environmental problem due to the irregular production and abuse of macrolide antibiotics. Microbial degradation is one of the most effective methods to deal with antibiotic pollution. This review summarizes the current status of environmental pollution caused by macrolide antibiotics, the degradation strains, the degradation enzymes, the degradation pathways and the microbial processes for degrading macrolide antibiotics. Moreover, the critical challenges on the biodegradation of macrolide antibiotics were also discussed.