基于金属有机骨架的生物复合物抗逆性研究进展

Advances in anti-adversity of biological composites based on metal-organic frameworks

摘要:

金属有机骨架 (Metal-organic frameworks，MOFs) 由金属离子/簇和有机配体通过自组装形成，在催化、传感、能源和生物医药等领域有十分广泛的应用。近年来，金属有机骨架和生物活性物质结合引起了许多研究者的关注。金属有机骨架具有超大孔容、高比表面积、多样性结构组成等优势，使其可作为固定载体保护生物活性物质免受外界不良微环境的影响，包括高温、高压、有机溶剂等，从而提高生物活性物质的抗逆性。文中从金属有机骨架作为保护层提高不同种类生物活性物质抗逆性的角度进行了综述，并贯穿介绍了基于金属有机骨架的生物复合物的合成策略，旨在为相关领域的研究人员提供参考，促进基于金属有机骨架的生物复合物的实际应用。

关键词:金属有机骨架，酶，核酸，细胞，病毒，细菌，稳定性

Abstract:

Metal-organic frameworks (MOFs) are formed by self-assembly of metal ions or clusters with organic ligands, and are widely used in the fields of catalysis, sensing, energy and biomedicine. Recently, biological composites based on MOFs have attracted increasing attention. MOFs can be used as a platform for encapsulating bioactive substances due to the advantages such as large pore capacity, large specific surface area and diverse structure composition. These features can protect bioactive substances from adverse conditions, e.g. high temperature, high pressure, and organic solvents, thus improving the anti-adversity of bioactive substances. This review summarizes the advances of using MOFs as protective coatings to improve the anti-adversity of different bioactive substances, and introduces the synthesis strategy of MOFs-based biological composites, with the aim to promote the practical application of MOFs-based biological composites.

Key words:metal-organic frameworks, enzyme, nucleic acid, cell, virus, bacteria, stability