IFN-λ家族基因遗传多态性与HBV感染、病毒复制及清除的关系

Correlations between genetic polymorphism of IFN-λ family gene and HBV infection,virus replication and clearance

摘要:

乙型肝炎病毒(hepatitis B virus,HBV)感染是一个严重的全球性公共卫生问题。HBV感染后会引发肝炎，可进一步发展为肝硬化甚至恶化为肝癌。干扰素λ(interferon λ,IFN-λ)是干扰素家族的成员之一，是抗病毒防御的重要细胞因子。IFN-λ家族包括4个成员，分别为IFN-λ1、IFN-λ2、IFN-λ3和IFN-λ4，已有研究表明该家族基因的遗传多态性与HBV的复制和患者的治疗效果具有相关性。文中从遗传易感的角度总结了IFN-λ家族基因多态性在HBV的感染、患者的病程进展和治疗效果中扮演的角色，从而进一步了解其遗传多态性在HBV感染及其病程中的作用，为HBV感染的预防与患者的治疗提供理论基础，为该类细胞因子作为抗HBV药物的研发提供参考。

Abstract:

Hepatitis B virus (HBV) infection is one of the most serious public health problems.HBV infection could lead to hepatitis B,and even further develop into hepatic cirrhosis and hepatocellular carcinoma.Interferon lambda (IFN-λ) is a member of the interferon (IFN) family and an important cytokine for antiviral defense.There are four members in IFN-λ family,including IFN-λ1,IFN-λ2,IFN-λ3,and IFN-λ4.The genetic polymorphisms in the IFN-λ genes are associated with HBV replication and treatment response of HBV patients.In this review,we summarized the roles of genetic polymorphisms of the IFN-λ genes played in HBV infection,disease progression and treatment,with the aim to better understand their function.This review could serve as a reference for the HBV prevention and treatment of HBV patients,as well as for future clinical usage.