蛋白质组学中色谱保留时间对齐算法的研究进展

Advances of chromatogram retention time alignment algorithms in proteomics

摘要:

色谱是目前蛋白质组学流程中的一个基本环节，而色谱的保留时间对齐是有效提高鉴定和定量准确性的重要步骤之一。经过多年的发展，目前已经产生了一系列保留时间对齐算法。文中主要从可用性角度对蛋白质组学分析中色谱保留时间对齐算法及工具进行了系统总结，并对其发展趋势及应用方向进行了展望。

关键词:蛋白质组学;色谱;保留时间对齐;算法;软件

Abstract:

Chromatography is a basic process in the current proteomics workflow,and the retention time alignment of the chromatogram is one of the important steps to effectively improve the identification and quantification accuracy.After years of development,a series of algorithms for retention time alignment have been developed.This review summarizes the advances of chromatographic retention time alignment algorithms and tools for proteomics analysis from the perspective of proteomics users,and discusses the development and future application directions.

Key words:proteomics;chromatography;retention time alignment;algorithm;software