三萜皂苷生物合成相关糖基转移酶研究进展

The glycosyltransferases involved in triterpenoid saponin biosynthesis:a review

摘要:

三萜皂苷具有独特的化学性质和丰富的药理活性，在医药、保健品、化妆品、食品添加剂、农业等方面被广泛应用。尿苷二磷酸(UDP)依赖的糖基转移酶(UGTs)是催化三萜皂苷生成的关键酶，对三萜皂苷的结构及其药理活性多样性的形成有重要作用。文中基于UGTs来源及受体底物结构类型对参与植物三萜皂苷生物合成的UGTs进行了综述，并展望了UGTs在基于合成生物学技术实现三萜皂苷异源生物合成方面的应用前景，以期为三萜皂苷生物合成相关研究提供参考。

Abstract:

Triterpenoid saponins are widely used in medicine,health cares,cosmetics,food additives and agriculture because of their unique chemical properties and rich pharmacological activities.UDP-dependent glycosyltransferases (UGTs) are the key enzymes involved in triterpenoid saponin biosynthesis,and play important roles in the diversity of triterpenoid saponin structures and pharmacological activities.This review summarized the UGTs involved in plant triterpenoid saponin biosynthesis based on the sources of UGTs and the types of receptors.Moreover,the application of UGTs in heterologous biosynthesis of triterpenoid saponins based on synthetic biology was also discussed.