合成生物制造

Biomanufacturing driven by engineered microbes

摘要:

本文对2021年《生物工程学报》在合成生物制造领域发表的综述和论文进行了评述。重点讨论了大肠杆菌、枯草芽孢杆菌、谷氨酸棒杆菌、酿酒酵母、丝状真菌以及非模式细菌、非传统酵母等主要底盘细胞的设计改造,氨基酸、有机酸、维生素、高级醇、天然化合物(萜类、黄酮类、生物碱类)、抗生素类、酶与生物催化产品、生物聚合物等产品的生物制造及生物质和一碳原料利用,以及构建细胞工厂所用到的调控、进化、高通量筛选等关键技术的进展情况。

Abstract:

This article summarized the reviews and research articles published in Chinese Journal of Biotechnology in the field of biomanufacturing in 2021.The article covered major chassis cells such as Escherichia coli,Bacillus subtilis,Corynebacterium glutamicum,Saccharomyces cerevisiae,filamentous fungi,non-model bacteria and non-conventional yeasts.Moreover,this article summarized the advances in the production of amino acids,organic acids,vitamins,higher alcohols,natural compounds (terpenoids,flavonoids,alkaloids),antibiotics,enzymes and enzyme-catalyzed products,biopolymers,as well as the utilization of biomass and one-carbon materials.The key technologies used in the construction of cell factories,such as regulation,evolution,and high-throughput screening,were also included.This article may help the readers better understand the R & D trend in biomanufacturing driven by engineered microbes.