As the content of static biochemistry is boring and traditional cramming education fails to draw the attention of students,we divided the course into small units and then made full use of "micro-teaching" resources such as multimedia slides,pictures,objects,experimental demonstrations and animations of the biochemical principles.The method created a"micro-teaching "environment,which combined boring static knowledge with vivid dynamic elements,thus producing a strong sensory impact on students,highlighting the knowledge in their mind,prompting students'participation,and greatly improving the teaching effects.This article introduces the goals and development process of this teaching method,and takes" Protein Denaturation and Renaturation "as an example to demonstrate the design and implementation process of the" micro-teaching",which seems to be of great significance to the improvement of the teaching quality of biochemistry course and serves as a reference for reform in other courses.