肠道菌群在肿瘤发生发展及免疫治疗中作用的研究进展

The role of intestinal microbiota in tumor occurrence, development and immunotherapy: a review

摘要:

肠道菌群是一个与人体共生的复杂微生物区系，近年来被越来越多的研究者所关注。研究发现，肠道菌群不仅在维持人体正常生理功能中起到重要作用，在肿瘤发生、发展、诊断及治疗中也有不可忽视的作用。本文在对肠道菌群与肿瘤关系进行概述的基础上，重点介绍了肠道菌群促进肿瘤发生、发展的主要机制，以及肠道菌群对抗肿瘤免疫治疗尤其是免疫检查点抑制疗法的影响。此外，文中还总结了目前可行的调节肠道菌群以提高肿瘤治疗疗效的方法，并提出了其中可能存在的困难和挑战。

Abstract:

The intestinal microbiota is a complex micro-ecological system symbiotic with human body, which has attracted increasing attention in recent years. The intestinal microbiota plays important roles not only in maintaining normal physiological functions of the human body but also in the occurrence, development, diagnosis and treatment of tumors. This review summarized the relationship between the intestinal microbiota and tumor, highlighting the mechanisms by which intestinal microbiota modulates tumor occurrence, development and immunotherapy, particularly the immune checkpoint therapy. This review also summarized the currently available methods for enhancing the efficacy of tumor therapy through regulation of intestinal microbiota. Challenges in the field as well as future perspectives were also discussed.