氨基酸对炎症性肠病的调控作用

Regulation of inflammatory bowel disease by amino acids

摘要:

炎症性肠病是胃肠道的一种慢性复发性炎症，包括克罗恩病和溃疡性结肠炎，患者众多，而且目前很难实现彻底治愈。由于患者消化功能受损，食物不容易吸收，很容易出现营养不良的情况，临床经常使用营养治疗来克服营养不足、改变炎症状态。氨基酸作为辅助营养治疗，可能有助于维持炎症性肠病患者的肠道完整性，减少炎症、氧化应激和肠道细胞死亡，对炎症性肠病的治疗起到积极的作用。最近在动物方面的研究已经证明氨基酸在炎症性肠病治疗中存在着巨大的潜力，氨基酸的供应和代谢可能是一种有前景的辅助治疗方法。本文就谷氨酰胺、精氨酸、甘氨酸等特定氨基酸的免疫调节作用进行综述，以期提供一种新的治疗炎症性肠病的思路。

Abstract:

Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease of the gastrointestinal tract that includes Crohn's disease and ulcerative colitis. IBD patients are numerous and a complete cure is difficult to achieve. Due to impaired digestive function, food is not easily absorbed and malnutrition often occurs in patients. Nutritional therapy is often used to overcome nutritional deficiency and change the inflammatory state in the clinic. Amino acids are adjuvant therapeutic candidates that may help maintain intestinal integrity in patients with IBD. It maypromote the treatment of IBD through reducing the level of inflammation, oxidative stress, and intestinal cell death. Recent studies in animals have demonstrated the potential of using amino acids for treating IBD. The supply and metabolism of amino acids may be a promising adjuvant therapy. This review summarized the immunomodulatory effects of specific amino acids such as glutamine, arginine, and glycine, with the aim to provide new ideas for the treatment of IBD.