动物模型在细菌生物被膜研究中的应用与展望

Animal models in bacterial biofilm research: a review

摘要:

细菌生物被膜的形成与其致病性、耐药性密切相关，在许多由细菌导致的慢性、亚慢性感染中发挥着重要作用。动物模型广泛应用于细菌生物被膜相关感染的研究中，为其致病机理和控制策略的探究提供了强有力的科学工具。因此，本文系统阐述了哺乳类(鼠、兔、猪等)和非哺乳类(黑腹果蝇、斑马鱼、秀丽隐杆线虫等)动物模型在细菌生物被膜相关研究中的应用，并对动物模型在细菌生物被膜研究中的应用前景进行了展望，以期为研究由生物被膜导致的相关感染而选择理想动物模型提供理论支撑，从而对生物被膜感染导致的潜在危害进行防控。

关键词:细菌;生物被膜;致病机理;动物模型

Abstract:

Biofilm formation is closely related to pathogenicity and antibiotic resistance of bacteria, and plays important roles in a number of chronic and subchronic infections. Animal models are widely used in the research of bacterial biofilm-associated infections, and provide a powerful scientific tool for investigating its pathogenesis and control strategies. This review summarized the application of mammalian models (e.g. mouse, rabbit, and pig) and non-mammalian models (e.g. Drosophila melanogaster, Zebrafish, and Caenorhabditis elegans) in bacterial biofilm studies, and prospects the application of animal models in biofilm. This review may facilitate the selection of suitable animal models in the study of biofilm-associated infections, so as to prevent and control the potential adverse effects.

Key words:bacteria;biofilm;pathogenic mechanism;animal models