Abstract:The rapid development of underlying technologies such as engineering biology and gene editing has promoted disruptive innovation in the area of industrial biotechnology. Industrial biotechnology has become the core technology supporting the innovation and development in low-carbon synthesis, future food and medicine development. Industrial biotechnology is becoming an important scientific and technological support for the transformation of traditional industrial manufacturing mode and the development of a carbon-neutral industrial manufacturing route. This review systematically summarizes the overall development of industrial biotechnology driven by Chinese Academy of Sciences with regard to strategic planning, innovation institutions building, talent pool development, basic research, scientific and technological innovation and industrial promotion, followed by suggestions for accelerating the development of industrial biotechnology.