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生物工程学报

2025年4月5日 21:06 星期六
首页 > 过刊浏览>2023年第39卷第3期 >930-941. DOI:10.13345/j.cjb.220623
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多级孔金属-有机框架固定化酶的研究进展
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河南高校青年骨干教师培养计划(2021GGJS047)


Advances in enzyme immobilization based on hierarchical porous metal-organic frameworks
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    摘要:

    金属-有机框架(metal-organic frameworks, MOFs)作为酶固定化的优良载体,为生物催化反应提供优越的物理和化学保护。近年来,多级孔金属-有机框架(hierarchical porous metal-organic frameworks, HP-MOFs)由于其独特的结构优势,在固定化酶方面显示出更大的潜力。到目前为止,已经开发了各类具有原生多级孔或缺陷多级孔的HP-MOFs用于酶的固定化研究,并且使得固定化酶在催化活性、稳定性和重复利用性等方面得到了显著增强。本文系统总结了HP-MOFs用于固定化酶的各种策略,介绍了HP-MOFs固定化酶(enzyme@HP-MOFs)在催化合成、生物传感、生物医药等领域的最新应用进展。最后,讨论并展望了HP-MOFs固定化酶这一领域所面临的挑战和机遇。

    Abstract:

    As an excellent hosting matrices for enzyme immobilization, metal-organic framework (MOFs) provides superior physical and chemical protection for biocatalytic reactions. In recent years, the hierarchical porous metal-organic frameworks (HP-MOFs) have shown great potential in enzyme immobilization due to their flexible structural advantages. To date, a variety of HP-MOFs with intrinsic or defective porous have been developed for the immobilization of enzymes. The catalytic activity, stability and reusability of enzyme@HP-MOFs composites are significantly enhanced. This review systematically summarized the strategies for developing enzyme@HP-MOFs composites. In addition, the latest applications of enzyme@HP-MOFs composites in catalytic synthesis, biosensing and biomedicine were described. Moreover, the challenges and opportunities in this field were discussed and envisioned.

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陈雅维,郑慧杰,曹倚婷,杨佳佳,周惠云. 多级孔金属-有机框架固定化酶的研究进展[J]. 生物工程学报, 2023, 39(3): 930-941

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  • 收稿日期:2022-08-05
  • 录用日期:2022-11-01
  • 在线发布日期: 2023-03-10
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