组织器官通讯对骨骼肌发育的作用及调控机制研究进展

The role and regulatory mechanism of tissue and organ crosstalk on skeletal muscle development: a review

摘要:

骨骼肌是动物机体最重要的器官之一，研究骨骼肌发育调控机制对于肌肉相关疾病的诊断以及家畜肉质的改善都有着重要意义。骨骼肌发育调控是一个复杂的过程，受到大量肌肉分泌因子和信号通路的调节。此外，为了维持体内代谢稳态并最大限度地利用能量，机体协调多个组织器官形成了复杂而又精密的代谢调控网络，对于调控骨骼肌发育也发挥着重要的作用。随着组学技术的发展，人们对于组织器官通讯的潜在机制进行了深入研究。本文综述了脂肪组织、神经组织、肠道等组织器官通讯对于骨骼肌发育的影响，以期为靶向调控骨骼肌发育提供理论基础。

Abstract:

Skeletal muscle is one of the most important organs in animal, and the regulatory mechanism of skeletal muscle development is of great importance for the diagnosis of muscle-related diseases and the improvement of meat quality of livestock. The regulation of skeletal muscle development is a complex process, which is regulated by a large number of muscle secretory factors and signaling pathways. In addition, in order to maintain steady-state and maximum use of energy metabolism in the body, the body coordinates multiple tissues and organs to form the complex and sophisticated metabolic regulation network, which plays an important role for the regulation of skeletal muscle development. With the development of omics technologies, the underlying mechanism of tissue and organ communication has been deeply studied. This paper reviews the effects of crosstalk among adipose tissue, nerve tissue and intestinal tissue on skeletal muscle development, with the aim to provide a theoretical basis for targeted regulation of skeletal muscle development.