MicroRNA调控猪骨骼肌发育的研究进展

Porcine skeletal muscle development regulated by MicroRNA: a review

摘要:

骨骼肌的生长发育是影响猪肉产量和品质的重要因素，其受遗传和营养等众多因素的精细调控。MicroRNA (miRNA)是一种长度约为22 nt的非编码RNA，通过与靶基因的mRNA 3'UTR序列结合，调控其转录后的表达发挥作用。近年来，大量的研究表明miRNA参与机体的生长发育、生殖、疾病等多种生命过程。本文对miRNA在猪骨骼肌发育调控中的作用进行了综述，以期为猪的遗传改良提供参考和借鉴。

Abstract:

The growth and development of skeletal muscle is an important factor affecting pork production and quality, which is elaborately regulated by many genetic and nutritional factors. MicroRNA (miRNA) is a non-coding RNA with a length of about 22 nt, which binds to the 3'UTR sequence of the mRNA of the target genes, and consequently regulates its post-transcriptional expression level. In recent years, a large number of studies have shown that miRNAs are involved in various life processes such as growth and development, reproduction, and diseases. The role of miRNAs in the regulation of porcine skeletal muscle development was reviewed, with the hope to provide a reference for the genetic improvement of pigs.