纳米材料治疗具核梭杆菌促进的结直肠癌研究进展

Advances on the treatment of Fusobacterium nucleatum-promoted colorectal cancers using nanomaterials

摘要:

具核梭杆菌(Fusobacterium nucleatum, Fn)是一种口腔厌氧菌，最近被发现在人类结直肠癌(colorectal cancer, CRC)细胞表面聚集，其富集程度与癌症治疗预后呈高度负相关。大量研究表明，Fn参与CRC的发生与发展过程，Fn与肿瘤微环境中多种组分相互作用从而增强肿瘤的耐药性。近年来，开始有研究利用纳米材料抑制Fn在肿瘤部位的增殖或通过直接靶向Fn治疗CRC。因此，本综述一方面将对近年来Fn在CRC中促肿瘤的机制进行梳理总结，另一方面将归纳整理不同纳米材料应用于Fn相关CRC治疗的最新研究进展，最后对纳米材料在Fn介导的CRC治疗中的应用前景进行了展望。

Abstract:

Fusobacterium nucleatum (Fn) is an oral anaerobic bacterium that has recently been found to colonize on the surface of colorectal cancer cells in humans, and its degree of enrichment is highly negatively correlated with the prognosis of tumor treatment. Numerous studies have shown that Fn is involved in the occurrence and development of colorectal cancer (CRC), and Fn interacts with multiple components in the tumor microenvironment to increase tumor resistance. In recent years, researchers have begun using nanomedicine to inhibit Fn’s proliferation at the tumor site or directly target Fn to treat CRC. This review summarizes the mechanism of Fn in promoting CRC and the latest research progress on Fn-related CRC therapy using different nanomaterials. Finally, the applications perspective of nanomaterials in Fn-promoted CRC therapy was prospected.