单增李斯特菌胎盘感染的体内外模型研究进展

Advances in in vitro and in vivo models for Listeria monocytogenes placental infection

摘要:

单核细胞增生李斯特氏菌（Listeria monocytogenes）是重要的食源性致病菌，能引发人类的李斯特菌病，是全球公共卫生问题之一。该菌易感染孕妇，引起胎儿和新生儿的侵袭性李斯特菌病，严重威胁母婴健康。因此，建立有效的单增李斯特菌感染胎盘体内外模型，解析和探究单增李斯特菌经胎盘感染机制，是预防和控制单增李斯特菌感染母婴的关键所在。本文综述了可用于研究单增李斯特菌母婴感染的体内外胎盘模型，总结和讨论了各类模型的优势和局限性；并着重分析了体外三维胎盘屏障模型在单增李斯特菌感染方面的研究进展和未来研究方向。以期为深入解析该菌经胎盘感染的途径、发病机制提供支持，并为预防和控制母婴李斯特菌病提供科学参考。

Abstract:

Listeria monocytogenes is recognized as a significant foodborne pathogen, capable of causing listeriosis in humans, which is a global public health concern. This pathogen is particularly dangerous for pregnant women, as it can lead to invasive listeriosis in fetuses and neonates, posing a significant threat to both maternal and fetal health. Therefore, establishing suitable in vitro and in vivo models for L. monocytogenes placenta infection, as well as analyzing and exploring the infection process and its pathogenic mechanism, are important approaches to prevent and control L. monocytogenes infection in mothers and infants. In this study, we reviewed the in vitro and in vivo placental models used for studying the infection of L. monocytogenes in maternal and infant, summarized and discussed the advantages and limitations of each model, and explored the potential of in vitro cell models and organoids for the study of L. monocytogenes infection. This paper aims to support the study of the infection pathway and pathogenesis of listeriosis and provide scientific references for the prevention and control of L. monocytogenes infection.