生物力对结直肠类器官培养的影响

Effects of biomechanics on colorectal organoid culture

摘要:

近年来，类器官已成为研究许多组织和器官生理病理过程的关键模型。各种类器官的出现推动了相应疾病在发生机制和临床转化等方面的研究，其中结直肠类器官模型较为成熟。结直肠癌是全球常见的消化道恶性肿瘤，严重威胁人类的身体健康。结直肠类器官为研究结直肠癌的病理生理、药物敏感性和精准医疗等方面提供了新的模型。传统的结直肠类器官培养系统更专注于生物化学因素的作用，忽视了肠道在体内还受生物物理信号影响。因此，本文就结直肠类器官和生物力学的相关理论及生物力对结直肠类器官的影响作一综述。

Abstract:

In recent years, organoids have become a crucial model for studying the physiopathological processes in tissues and organs. The emergence of organoids has promoted the research on the mechanisms of the occurrence and clinical translation of diseases. Among these organoid models, colorectal organoid models are increasingly mature. Colorectal cancer is a common gastrointestinal malignant tumor worldwide, posing a serious threat to human health. Colorectal organoids provide a new model for studying the pathophysiology, drug sensitivity, and precision medicine of colorectal cancer. The conventional culture systems of colorectal organoids focus more on the role of biochemical factors, neglecting the fact that the gut is also influenced by biophysical signals in vivo. Therefore, in this review, we discuss the theories related to colorectal organoids and biomechanics and expound the effects of biomechanics on colorectal organoid culture.