mRNA纳米递送系统在CAR-T肿瘤免疫治疗中的应用

Application of mRNA nano-delivery system in CAR-T tumor immunotherapy

摘要:

嵌合抗原受体T细胞(chimeric antigen receptor T cells, CAR-T)免疫疗法能够激活系统特异性免疫来实现抗肿瘤效应，近年来取得了令人振奋的进展。mRNA纳米递送系统以纳米颗粒包裹肿瘤免疫治疗相关抗原的mRNA，一方面能直接靶向于T细胞生成CAR-T细胞，直接作用于相应肿瘤细胞；另一方面可以通过靶向递送至抗原提呈细胞，辅助性增强CAR-T细胞功能，进一步诱导对肿瘤细胞产生特异性免疫反应，因而在CAR-T肿瘤免疫治疗中展现出巨大的潜力。本文就mRNA纳米递送系统的合成及其在CAR-T肿瘤免疫治疗中的研究和应用进行了综述。

Abstract:

Chimeric antigen receptor T cells (CAR-T) immunotherapy, which activates immunity specific to the system in order to achieve antitumor effects, has experienced exciting progress in recent years. mRNA nano-delivery systems, which encapsulate tumor immunotherapy-related antigen mRNA with nanoparticles, have shown great potential in CAR-T tumor immunotherapy. On one hand, these systems can directly target T cells to generate CAR-T cells that directly act upon the corresponding tumor cells. On the other hand, they can be delivered to antigen-presenting cells through targeting, thereby enhancing the function of CAR-T cells and further inducing specific immune responses against tumor cells. This review summarizes the synthesis of mRNA nano-delivery systems and their application in CAR-T tumor immunotherapy.