刺激响应型脂质体的构建策略及其生物学应用

Construction strategy of stimuli-responsive liposome and its biological application

摘要:

刺激响应型脂质体作为一种新型纳米载体，已广泛应用于医学、食品及化妆品领域。本文围绕刺激响应型脂质体的制备方式、构建策略及其生物学应用展开了详细的介绍。其中，重点综述了pH敏感型、氧化还原敏感型、酶敏感型、热敏型、光敏型和磁场响应型脂质体的功能原理，并根据给药方式的不同对其应用进行了总结归纳。最后，本文对当前刺激响应型脂质体面临的问题与发展前景作出了概括展望。

Abstract:

Stimuli-responsive liposomes, a novel type of nanocarriers, have been widely used in the fields of medicine, food, and cosmetics. This paper provides a comprehensive introduction to the preparation methods, construction strategies, and biological applications of stimuli-responsive liposomes. The review highlights the functional principles of pH-sensitive, redox-sensitive, enzyme-sensitive, heat-sensitive, light-sensitive, and magnetic field-responsive liposomes, and summarizes their applications based on various drug delivery mode. Finally, the article provides an overview of the current challenges and future development prospects for stimuli-responsive liposomes.