微生物化学品工厂专刊序言

Preface for special issue on Microbial Chemical Factories

摘要:

微生物化学品工厂以工程化设计理念，通过最优合成途径设计、生化网络重构、新元件创制及与途径-细胞-环境适配，重塑自然生产线，实现化学品的精准、定量、高效合成。作为一种颠覆性化学品生产新模式，微生物化学品工厂对构建工业经济发展的可再生原料路线、推进物质财富的绿色增长具有重大意义，成为发达国家科技竞争和产业发展的重点。为了集中展现微生物化学品工厂领域取得的最新进展，并促进生物制造产业的快速进步，《生物工程学报》特组织出版“微生物化学品工厂”专刊，汇集了国内科研工作者在材料单体、医药中间体、功能食品配料、有机酸生物合成以及非粮原料开发利用方面的最新研究成果，为微生物化学品工厂的高质量发展提供借鉴与指导。

关键词:细胞工厂;化学品生产;合成生物学;代谢工程;微生物制造

Abstract:

Microbial chemical factories utilize engineering design principles to re-build natural production pathways, enabling the precise, quantitative, and efficient synthesis of chemicals. This is achieved through the optimization of synthetic pathways, the reconstruction of biochemical networks, the development of novel components, and the integration of pathways with cellular and environmental contexts. As a transformative approach to chemical production, microbial chemical factories play a critical role in establishing renewable raw material pathways for industrial economic development and advancing sustainable growth. This innovative model has become a strategic priority for technological advancement and industrial competitiveness in developed nations. This industry has expanded into diverse sectors, including pharmaceuticals, food production, chemicals, and energy. To showcase the most recent scientific advancements in the field of microbial chemical production and to promote the evolution of the bio-manufacturing industry, we organized a special issue entitled “Microbial Chemical Factories”. This edition features the latest research conducted by domestic scientists, focusing on areas such as the synthesis of material monomers, pharmaceutical intermediates, functional food ingredients, organic acid biosynthesis, and the development and utilization of non-food feedstock. It provides reference and guidance for the further development of microbial chemical factories.

Key words:cell factories;chemical production;synthetic biology;metabolic engineering;microbial manufacturing