稀有糖D-阿洛糖的生理功能研究进展
作者:
基金项目:

国家自然科学基金(81971227)


Research progress in physiological function of the rare sugar D-allose
Author:
  • 摘要
  • | |
  • 访问统计
  • |
  • 参考文献 [55]
  • | | | |
  • 文章评论
    摘要:

    D-阿洛糖(D-allose)是一种稀有糖,具有抗氧化、抗炎、抗癌、免疫抑制等多种生理学功能,成为近年来的研究热点。本文对D-阿洛糖的理化性质、合成方法、体内代谢和其生理功能以及在食品和医疗领域的应用等方面进行了综述,以期促进D-阿洛糖的功能研究,为D-阿洛糖在食品领域及临床治疗中的应用提供参考。

    Abstract:

    D-allose, a rare sugar with anti-oxidant, anti-inflammatory, anti-cancer, immunosuppressing and other physiological functions, has become a research hotspot in recent years. This paper describes the physical and chemical properties, synthesis methods, metabolism, physiological functions, and applications of D-allose, aiming to promote the functional development of D-allose and facilitate the application of D-allose in the food field and clinical treatment.

    参考文献
    [1] XIA Y, CHENG QQ, MU WM, HU XY, SUN Z, QIU YY, LIU XM, WANG ZP. Research advances of d-allulose: an overview of physiological functions, enzymatic biotransformation technologies, and production processes[J]. Foods, 2021, 10(9): 2186.
    [2] MOCHIZUKI S, FUKUMOTO T, OHARA T, OHTANI K, YOSHIHARA A, SHIGEMATSU Y, TANAKA K, EBIHARA K, TAJIMA S, GOMI K, ICHIMURA K, IZUMORI K, AKIMITSU K. The rare sugar d-tagatose protects plants from downy mildews and is a safe fungicidal agrochemical[J]. Communications Biology, 2020, 3(1): 423.
    [3] GAO DK, KAWAI N, NAKAMURA T, LU F, FEI Z, TAMIYA T. Anti-inflammatory effect of D-allose in cerebral ischemia/reperfusion injury in rats[J]. Neurologia Medico-Chirurgica, 2013, 53(6): 365-374.
    [4] NAKAMURA T, TANAKA S, HIROOKA K, TOYOSHIMA T, KAWAI N, TAMIYA T, SHIRAGA F, TOKUDA M, KEEP RF, ITANO T, MIYAMOTO O. Anti-oxidative effects of D-allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat[J]. Neuroscience Letters, 2011, 487(1): 103-106.
    [5] ARNOLD EC, SILADY PJ. Use of D-allose as an immunosuppressive agent: US5620960[P]. 1997-04-15.
    [6] 代艺伟. 多酶催化体系转化麦芽糊精合成d-塔格糖的研究[D]. 无锡: 江南大学博士学位论文, 2021. DAI YW. Biosynthesis of d-tagatose from maltodextrin by multi-enzyme catalytic system[D]. Wuxi: Doctoral Dissertation of Jiangnan University, 2021(in Chinese).
    [7] 倪娓娓, 胡超群, 白福来, 季文娜, 张茜. d-甘露糖生产工艺及生理功能研究进展[J]. 食品工业科技, 2022, 43(17): 458-465. NI WW, HU CQ, BAI FL, JI WN, ZHANG Q. Research progress on the production technology and physiological function of d-mannose[J]. Science and Technology of Food Industry, 2022, 43(17): 458-465(in Chinese).
    [8] IGA Y, NAKAMICHI K, SHIRAI Y, MATSUO T. Acute and sub-chronic toxicity of D-allose in rats[J]. Bioscience, Biotechnology, and Biochemistry, 2010, 74(7): 1476-1478.
    [9] 段爽爽. l-鼠李糖异构酶转化d-阿洛酮糖产D-阿洛糖的研究[D]. 济南: 齐鲁工业大学硕士学位论文, 2023. DUAN SS. Conversion of d-psicose by l-rhamnose isomerase to produce D-allose[D]. Jinan: Master’s Thesis of Qilu University of Technology, 2023(in Chinese).
    [10] IZUMORI K. Izumoring: a strategy for bioproduction of all hexoses[J]. Journal of Biotechnology, 2006, 124(4): 717-22.
    [11] 刘梦璐, 袁卫涛, 李宁, 杨艳宇, 曹建帮, 高学秀. 功能性甜味剂d-阿洛酮糖研究进展[J]. 中国食品添加剂, 2022, 33: 21-25. LIU ML, YUAN WT, LI N, YANG YY, CAO JB, GAO XX. Research progress on functional sweetener d-allulose[J]. China Food Additives, 2022, 33: 21-25(in Chinese).
    [12] 郭元亨, 王靖, 王小艳, 陶进, 陈博, 李义, 佟毅. 我国生物合成d-阿洛酮糖的研究及产业化进展[J]. 现代食品, 2020: 34-40. Guo YH, Wang J, Wang XY, TAO J, CHEN B, LI Y, TONG Y. Research and industrialization progress of d-psicose in China[J]. Modern Food, 2020: 34-40(in Chinese).
    [13] 郑灵洁. 大肠杆菌合成D-阿洛糖的途径设计与发酵优化[D]. 北京: 北京化工大学硕士学位论文, 2021. ZHENG LJ. Metabolic engineering of Escherichia coli for D-allose synthesis and its fermentation optimization[D]. Beijing: Master’s Thesis of Beijing University of Chemical Technology, 2021(in Chinese)
    [14] 陈红. 基于CRISPR/Cas9技术改造酿酒酵母合成D-阿洛糖的研究[D]. 广州: 华南理工大学硕士学位论文, 2020. CHEN H. Research on the synthesis of D-allose with engineered Saccharomyces cerevisiae via CRISPR/Cas9[D]. Guangzhou: Master’s Thesis of South China University of Technology, 2020(in Chinese).
    [15] CHOI MN, SHIN KC, KIM DW, KIM BJ, PARK CS, YEOM SJ, KIM YS. Production of D-allose from d-allulose using commercial immobilized glucose isomerase[J]. Frontiers in Bioengineering and Biotechnology, 2021, 9: 681253.
    [16] KISHIDA K, IIDA T, YAMADA T, TOYODA Y. D-allose is absorbed via sodium-dependent glucose cotransporter 1(SGLT1) in the rat small intestine[J]. Metabolism Open, 2021, 11: 100112.
    [17] SHINTANI T, YANAI SC, KANASAKI A, TANAKA M, IIDA T, OZAWA G, KUNIHIRO T, ENDO S. Long-term D-allose administration favorably alters the intestinal environment in aged male mice[J]. Journal of Applied Glycoscience, 2022, 69(4): 97-102.
    [18] JIANG SW, XIAO W, ZHU XX, YANG PZ, ZHENG Z, LU SH, JIANG ST, ZHANG GC, LIU JJ. Review on d-allulose: in vivo metabolism, catalytic mechanism, engineering strain construction, bio-production technology[J]. Frontiers in Bioengineering and Biotechnology, 2020, 8: 26.
    [19] HIROOKA K, KIUCHI Y. The retinal renin-angiotensin-aldosterone system: implications for glaucoma[J]. Antioxidants, 2022, 11(4): 610.
    [20] LIU YN, NAKAMURA T, TOYOSHIMA T, SHINOMIYA A, TAMIYA T, TOKUDA M, KEEP RF, ITANO T. The effects of D-allose on transient ischemic neuronal death and analysis of its mechanism[J]. Brain Research Bulletin, 2014, 109: 127-131.
    [21] MUNEUCHI G, HOSSAIN A, YAMAGUCHI F, UENO M, TANAKA Y, SUZUKI S, TOKUDA M. The rare sugar D-allose has a reducing effect against ischemia-reperfusion injury on the rat abdominal skin island flap model[J]. Journal of Surgical Research, 2013, 183(2): 976-981.
    [22] KASHIWAGI H, ASANO E, NOGUCHI C, SUI L, HOSSAIN A, AKAMOTO S, OKANO K, TOKUDA M, SUZUKI Y. Beneficial effect of D-allose for isolated islet culture prior to islet transplantation[J]. Journal of Hepato-Biliary-Pancreatic Sciences, 2016, 23(1): 37-42.
    [23] OZAKI T, FU HY, ONISHI K, YOKOYAMA S, FUJITA T, TOBIUME A, SOFUE T, AKIMITSU K, MINAMINO T. Partial replacement of d-glucose with D-allose ameliorates peritoneal injury and hyperglycaemia induced by peritoneal dialysis fluid in rats[J]. Peritoneal Dialysis International, 2023: 8968608231184354.
    [24] ZHENG LJ, GUO Q, ZHANG YX, LIU CY, FAN LH, ZHENG HD. Engineering of Escherichia coli for D-allose fermentative synthesis from d-glucose through izumoring cascade epimerization[J]. Frontiers in Bioengineering and Biotechnology, 2022, 10: 1050808.
    [25] MOORADIAN AD, HAAS MJ, ONSTEAD-HAAS L, TANI YM, IIDA T, TOKUDA M. Naturally occurring rare sugars are free radical scavengers and can ameliorate endoplasmic reticulum stress[J]. International Journal for Vitamin and Nutrition Research, 2020, 90(3/4): 210-220.
    [26] SHINTANI T, SAKOGUCHI H, YOSHIHARA A, IZUMORI K, SATO M. D-allose, a stereoisomer of d-glucose, extends the lifespan of Caenorhabditis elegans via sirtuin and insulin signaling[J]. Journal of Applied Glycoscience, 2019, 66(4): 139-142.
    [27] JU JH, HOU RX, ZHANG P. D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1[J]. Molecular Medicine, 2020, 26(1): 21.
    [28] 郑锐哲, 毛旻韬, 杨西涛, 刘玉梅. 辅酶Q10通过抑制炎症损伤及细胞凋亡保护创伤性颅脑损伤[J]. 实用医学杂志, 2021, 37: 446-450. Zheng RZ, Mao MT, Yang XT, LIU YM. Protective effects of coenzyme Q10 on traumatic brain injury by inhibiting inflammatory injury and cell apoptosis[J]. The Journal of Practical Medicine, 2021, 37: 446-450(in Chinese).
    [29] 王小巍, 张红艳, 刘锐, 王东凯. 谷胱甘肽的研究进展[J]. 中国药剂学杂志(网络版), 2019, 17(4): 141-148. WANG XW, ZHANG HY, LIU R, WANG DK. Progress in research of glutathione[J]. Chinese Journal of Pharmaceutics (Online Edition), 2019, 17(4): 141-148(in Chinese).
    [30] 贺奇凯, 黄丽娜. 硫辛酸的抗氧化临床应用最新研究进展[J]. 世界最新医学信息文摘, 2019, 19(16): 104, 106. HE QK, HUANG LN. The latest research progress of clinical application of lipoic acid in antioxidation[J]. World Latest Medicine Information, 2019, 19(16): 104, 106(in Chinese).
    [31] GAO DK, KAWAI N, TAMIYA T. The anti-inflammatory effects of D-allose contribute to attenuation of cerebral ischemia-reperfusion injury[J]. Medical Hypotheses, 2011, 76(6): 911-913.
    [32] HUANG T, GAO DK, HEI Y, ZHANG X, CHEN XY, FEI Z. D-allose protects the blood brain barrier through PPARγ-mediated anti-inflammatory pathway in the mice model of ischemia reperfusion injury[J]. Brain Research, 2016, 1642: 478-486.
    [33] 罗耀文, 程俊凯, 张敏, 苟茂荣, 李娟, 张磊, 高大宽. D-阿洛糖下调半乳糖凝集素-3抑制AMPK/mTOR通路减轻脑缺血再灌注损伤[J]. 安徽医科大学学报, 2023, 58: 1467-1473. LUO YW, CHENG JK, ZHANG M, GOU MR, LI J, ZHANG L, GAO DK. D-allose alleviate cerebral ischemia-reperfusion injury by down-regulating galectin-3 inhibition of the AMPK/mTOR pathway[J]. Acta Universitatis Medicinalis Anhui, 2023, 58: 1467-1473(in Chinese).
    [34] 张敏, 费晓炜, 罗耀文, 付奕豪, 张磊, 高大宽. D-阿洛糖对OGD/R诱导的HT22细胞损伤及Gal-3表达的影响[J]. 中华神经创伤外科电子杂志, 2023, 9: 135-141. Zhang M, Fei XW, Luo YW, FU YH, ZHANG L, GAO DK. Effects of D-allose on OGD/R-induced HT22 cell damage and Gal-3 expression[J]. Chinese Journal of Neurotraumatic Surgery: Electronic Edition, 2023, 9: 135-141(in Chinese).
    [35] LUO YW, CHENG JK, FU YH, ZHANG M, GOU MR, LI J, LI XB, BAI J, ZHOU YF, ZHANG L, GAO DK. D-allose inhibits TLR4/PI3K/AKT signaling to attenuate neuroinflammation and neuronal apoptosis by inhibiting gal-3 following ischemic stroke[J]. Biological Procedures Online, 2023, 25(1): 30.
    [36] ISKANDER A, YAN LJ. Cisplatin-induced kidney toxicity: potential roles of major NAD+-dependent enzymes and plant-derived natural products[J]. Biomolecules, 2022, 12(8): 1078.
    [37] HE J, ZHOU D, YAN B. Eriocitrin alleviates oxidative stress and inflammatory response in cerebral ischemia reperfusion rats by regulating phosphorylation levels of Nrf2/NQO-1/HO-1/NF-κB p65 proteins[J]. Annals of Translational Medicine, 2020, 8(12): 757.
    [38] NOGUCHI C, KAMITORI K, HOSSAIN A, HOSHIKAWA H, KATAGI A, DONG YY, SUI L, TOKUDA M, YAMAGUCHI F. D-allose inhibits cancer cell growth by reducing GLUT1 expression[J]. The Tohoku Journal of Experimental Medicine, 2016, 238(2): 131-141.
    [39] TOHI Y, TAOKA R, ZHANG X, MATSUOKA Y, YOSHIHARA A, IBUKI E, HABA R, AKIMITSU K, IZUMORI K, KAKEHI Y, SUGIMOTO M. Antitumor effects of orally administered rare sugar D-allose in bladder cancer[J]. International Journal of Molecular Sciences, 2022, 23(12): 6771.
    [40] KHAJEH S, GANJAVI M, PANAHI G, ZARE M, ZARE M, TAHAMI SM, RAZBAN V. D-allose: molecular pathways and therapeutic capacity in cancer[J]. Current Molecular Pharmacology, 2023, 16(8): 801-810.
    [41] JEONG RU, LIM S, KIM MO, MOON MH. Effect of D-allose on prostate cancer cell lines: phospholipid profiling by nanoflow liquid chromatography-tandem mass spectrometry[J]. Analytical and Bioanalytical Chemistry, 2011, 401(2): 689-698.
    [42] ISHIYAMA H, YANAGITA RC, TAKEMOTO K, KOBASHI K, SUGIYAMA Y, KAWANAMI Y. Development of a D-allose-6-phosphate derivative with anti-proliferative activity against a human leukemia MOLT-4F cell line[J]. Carbohydrate Research, 2020, 487: 107859.
    [43] PENG X, ZHANG SL, JIAO WH, ZHONG ZX, YANG YQ, CLARET FX, ELKABETS M, WANG F, WANG R, ZHONG YX, CHEN ZS, KONG DX. Hydroxychloroquine synergizes with the PI3K inhibitor BKM120 to exhibit antitumor efficacy independent of autophagy[J]. Journal of Experimental & Clinical Cancer Research, 2021, 40(1): 374.
    [44] DENG JH, PAN T, LIU ZQ, McCARTHY C, VICENCIO JM, CAO LL, ALFANO G, SUWAIDAN AA, YIN MZ, BEATSON R, NG T. The role of TXNIP in cancer: a fine balance between redox, metabolic, and immunological tumor control[J]. British Journal of Cancer, 2023, 129(12): 1877-1892.
    [45] FUKUNAGA K, YOSHIMURA T, IMACHI H, KOBAYASHI T, SAHEKI T, SATO S, SAHEKI N, JIANG WY, MURAO K. A pilot study on the efficacy of a diabetic diet containing the rare sugar d-allulose in patients with type 2 diabetes mellitus: a prospective, randomized, single-blind, crossover study[J]. Nutrients, 2023, 15(12): 2802.
    [46] HOSSAIN MA, IZUISHI K, MAETA H. Protective effects of D-allose against ischemia reperfusion injury of the rat liver[J]. J Hepatobiliary Pancreat Surg, 2003, 10(3): 218-25.
    [47] TANAKA S, SAKAMOTO H. Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells[J]. Cellular Immunology, 2011, 271(1): 141-146.
    [48] WU J, LI S, LI TT, LV XP, ZHANG MY, ZANG GX, QI C, LIU YJ, XU L, CHEN JT. pDC activation by TLR7/8 ligand CL097 compared to TLR7 ligand IMQ or TLR9 ligand CpG[J]. Journal of Immunology Research, 2019, 2019: 1749803.
    [49] CHEN XW, GU XJ, YANG J, JIANG ZF, DENG JJ. Gas chromatography-mass spectrometry technology: application in the study of inflammatory mechanism in COVID-19 patients[J]. Chromatographia, 2023, 86(2): 175-183.
    [50] 伍维高, 钟金凤. 环磷酰胺构建动物免疫抑制模型的研究进展[J]. 中国兽医杂志, 2019, 55(2): 87-89. WU WG, ZHONG JF. Research progress in constructing animal immunosuppressive model with cyclophosphamide[J]. Chinese Journal of Veterinary Medicine, 2019, 55(2): 87-89(in Chinese).
    [51] 田普训, 敖建华, 李宁, 石炳毅. 器官移植免疫抑制剂临床应用技术规范(2019版)[J]. 器官移植, 2019, 10(3): 213-226. TIAN PX, AO JH, LI N, SHI BY. Technical specification for clinical application of immunosuppressants in organ transplantation (2019 edition)[J]. Organ Transplantation, 2019, 10(3): 213-226(in Chinese).
    [52] 李玲, 郭宏丽, 胡雅慧, 李运曼, 方伟蓉, 赵非, 许静, 陈峰. 他克莫司在儿童肾病综合征群体中的治疗药物监测[J]. 中国药学杂志, 2021, 56(23): 1880-1886. LI L, GUO HL, HU YH, LI YM, FANG WR, ZHAO F, XU J, CHEN F. Therapeutic drug monitoring of tacrolimus in children with nephrotic syndrome[J]. Chinese Pharmaceutical Journal, 2021, 56(23): 1880-1886(in Chinese).
    [53] IIZUKA K. Is the use of artificial sweeteners beneficial for patients with diabetes mellitus? The advantages and disadvantages of artificial sweeteners[J]. Nutrients, 2022, 14(21): 4446.
    [54] SOMJAI C, SIRIWOHARN T, KULPRACHAKARN K, CHAIPOOT S, PHONGPHISUTTHINANT R, WIRIYACHAREE P. Utilization of Maillard reaction in moist-dry-heating system to enhance physicochemical and antioxidative properties of dried whole Longan fruit[J]. Heliyon, 2021, 7(5): e07094.
    [55] ZHANG M, FU YH, LUO YW, GOU MR, ZHANG L, FEI Z, GAO DK. D-allose protects brain microvascular endothelial cells from hypoxic/reoxygenated injury by inhibiting endoplasmic reticulum stress[J]. Neuroscience Letters, 2023, 793: 137000.
    相似文献
    引证文献
    网友评论
    网友评论
    分享到微博
    发 布
引用本文

张敏,杨舒雅,高大宽. 稀有糖D-阿洛糖的生理功能研究进展[J]. 生物工程学报, 2024, 40(7): 2010-2021

复制
分享
文章指标
  • 点击次数:305
  • 下载次数: 1160
  • HTML阅读次数: 397
  • 引用次数: 0
历史
  • 收稿日期:2023-08-03
  • 在线发布日期: 2024-07-08
  • 出版日期: 2024-07-25
文章二维码
您是第5998159位访问者
生物工程学报 ® 2025 版权所有

通信地址:中国科学院微生物研究所    邮编:100101

电话:010-64807509   E-mail:cjb@im.ac.cn

技术支持:北京勤云科技发展有限公司