微生物利用CO2及其低碳衍生物为原料制备粮食类产物的研究进展
作者:
  • 白振敏

    白振敏

    中海石油化学股份有限公司, 北京 100029;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 郭姝媛

    郭姝媛

    中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 合成生物化学研究中心, 广东 深圳 518055;中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 定量合成生物学重点实验室, 深圳 518055;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 杨一群

    杨一群

    中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 合成生物化学研究中心, 广东 深圳 518055;中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 定量合成生物学重点实验室, 深圳 518055;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 庄周康

    庄周康

    中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 合成生物化学研究中心, 广东 深圳 518055;中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 定量合成生物学重点实验室, 深圳 518055;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 曹文兵

    曹文兵

    中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 合成生物化学研究中心, 广东 深圳 518055;中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 定量合成生物学重点实验室, 深圳 518055;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 杨研

    杨研

    中海石油化学股份有限公司, 北京 100029;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 于涛

    于涛

    中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 合成生物化学研究中心, 广东 深圳 518055;中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 定量合成生物学重点实验室, 深圳 518055;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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  • 汤红婷

    汤红婷

    中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 合成生物化学研究中心, 广东 深圳 518055;中国科学院深圳先进技术研究院 深圳合成生物学创新研究院 定量合成生物学重点实验室, 深圳 518055;中国科学院深圳先进技术研究院 碳中和与粮食安全交叉创新联合实验室, 广东 深圳 518055
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基金项目:

国家重点研发计划(2021YFA0911000);国家自然科学基金(32071416);广东省重点区域研究与发展计划项目(2022B1111080005); 深圳合成生物学创新研究院科研基金(JCHZ20200003); 深圳市科技计划(ZDSYS20210623091810032);中国科学院战略重点研究项目(XDB0480000)


Microbial production of food compounds with carbon dioxide and derived low-carbon molecules as substrates
Author:
  • BAI Zhenmin

    BAI Zhenmin

    China BlueChemical Ltd., Beijing 100029, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • GUO Shuyuan

    GUO Shuyuan

    Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • YANG Yiqun

    YANG Yiqun

    Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • ZHUANG Zhoukang

    ZHUANG Zhoukang

    Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • CAO Wenbing

    CAO Wenbing

    Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • YANG Yan

    YANG Yan

    China BlueChemical Ltd., Beijing 100029, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • YU Tao

    YU Tao

    Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • TANG Hongting

    TANG Hongting

    Center for Synthetic Biochemistry, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;CAS Key Laboratory of Quantitative Engineering Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China;Carbon Neutrality and Food Security Cross-Innovation Joint Laboratory, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China
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  • 摘要
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  • 访问统计
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  • 参考文献 [77]
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  • 文章评论
    摘要:

    微生物细胞工厂的构建和优化是实现绿色生物制造的重要环节和关键技术。现阶段,过量二氧化碳(CO2)排放和粮食短缺等问题已经引起了广泛关注,这促进了利用人工微生物将CO2转化为粮食类化合物这一新兴研究方向的发展。该领域的研究不仅有助于实现“双碳”目标,也对维护粮食安全具有重大意义。本文主要围绕葡萄糖、糖类衍生物、单细胞蛋白的生物合成及人工碳固定途径的开发及应用等方面,对直接或者间接利用CO2制备粮食类化合物的研究进展进行了综述和展望。

    Abstract:

    The construction and optimization of microbial cell factories are crucial steps and key technologies in achieving green biomanufacturing. As concern has been aroused regarding the excessive carbon dioxide (CO2) emissions and food security, a new and promising research field, microbial conversion of CO2 into food compounds, has emerged. The research in this field not only holds significant implications for achieving the carbon peaking and carbon neutrality goals but also plays a role in maintaining food security. This paper provides a comprehensive review and outlook of the research on utilizing CO2 and its derived low-carbon chemicals for the production of food compounds, focusing on the production of glucose, sugar derivatives, and single-cell proteins and the development of artificial CO2 fixation pathways.

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白振敏,郭姝媛,杨一群,庄周康,曹文兵,杨研,于涛,汤红婷. 微生物利用CO2及其低碳衍生物为原料制备粮食类产物的研究进展[J]. 生物工程学报, 2024, 40(8): 2731-2746

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