mRNA疫苗翻译效率的研究进展

Research progress in the translation efficiency of mRNA vaccines

摘要:

面向快速应对新发传染病的需求，与传统疫苗相比，mRNA疫苗技术在设计、生产和应用等方面具有优势，在新型冠状病毒疫情期间率先获得世界卫生组织的紧急使用推荐。mRNA疫苗设计的关键之一是确保编码蛋白在受种者体内稳定、充分表达。本文综述了近年来在提高mRNA疫苗翻译效率方面的相关研究进展和存在的问题，以期为相关研究提供帮助。

Abstract:

Compared with conventional vaccines, mRNA vaccines have considerable advantages in design, production, and application, especially in dealing with emerging infectious diseases. Particularly, mRNA vaccines were the first to be recommended by the World Health Organization for emergency use during the COVID-19 pandemic. A key to the design of mRNA vaccines is to ensure the stable and sufficient expression of the encoded protein in the recipient. In recent years, advances have been attained in the experimental and computational research in this area. This review focused on the progress and problems in improving the translation efficiency of mRNA vaccines in recent years, aiming to promote related research.