过程工程在木质纤维素发酵抑制物解除中的应用

Application of process engineering to remove lignocellulose fermentation inhibitors

摘要:

发酵抑制物对宿主细胞产生毒害作用，是木质纤维素生物炼制的主要瓶颈之一。减少抑制物含量、解除抑制作用是提高发酵效率的重要环节。本文讨论了木质纤维素发酵抑制物的来源、组成、特点以及相应的解除方法，提出了“源头降低抑制物—纤维素木质素分级转化”炼制模式和“发酵促进剂设计技术”，为木质纤维素发酵抑制物的解除及木质纤维素开发利用提供了全新的技术路线。

Abstract:

Fermentation inhibitors are toxic to cells, which is one of the bottlenecks for lignocellulose bio-refinery process. How to remove those inhibitors serves a key role in the bioconversion of lignocellulose. This article reviews the sources and the types of the inhibitors, especially the updated removal strategies including physical methods, chemical methods, biological methods and inhibitor-tolerant strain construction strategies. Based on these, we introduce a new bio-refinery model named “fractional conversion”, which reduces the production of inhibitors at pretreatment stage and a novel in situ detoxification method named “fermentation promoter exploitation technology”. This review could provide new research ideas on the removal of fermentation inhibitors.