结核病新抗生素靶标和抑制剂研发

Progress in role of novel anti-tuberculosis drug targets and their inhibitors

摘要:

随着结核病耐药现象越来越严重，迫切需要开发新型抗结核药物，而大部分的药物开发主要依赖于新型的抗生素靶标的发现。文中综述了2016年以来新出现的具有开发为抗结核药物潜力的新化合物，并重点阐述了这些新化合物所针对的抗生素靶标，将有助于针对这些靶标进一步开发新型抗结核药物。

Abstract:

There is an urgent need to discover new anti-tuberculosis compounds with novel mechanisms of action in order to deal with tuberculosis and drug-resistant tuberculosis. In this article, the feature of several promising novel compounds with potential anti-tuberculosis activities is summarized, focusing on the drug targets of these compounds. These summaries will contribute to the further development of anti-tuberculosis drugs.