微生物源农用抗生素的研发与高产策略

Development and high yield strategies of microbial-derived antibiotics in agriculture

摘要:

开发高效、低毒、低残留的绿色农药是农药研发的发展趋势，其中微生物源农药抗生素占据了重要地位。随着基因组学、代谢工程、高通量筛选等技术的发展，新型微生物源农用抗生素的研究进入了新的阶段。文中简要总结了近10年来研发的新型微生物源农用抗生素的种类、农用抗生素产生菌株的高产育种与发酵研究策略等，为未来农用抗生素的研发提供参考。

Abstract:

The development of high-efficiency, low-toxicity, and low-residue green pesticides is the main trend of pesticide research, and the microbial-derived antibiotics are one of the essential parts of green pesticides and play a significant role in agriculture. With the development of microbial genomics technology, metabolic engineering, high-throughput screening and other technologies, the research on new microbial-derived antibiotics has entered a new stage in agriculture. Here we briefly summarize the types of new microbial-derived antibiotics developed in agriculture over the past decade. We also introduce the research strategies for high-yield breeding and fermentation of antibiotic-producing strains in agriculture. This review may provide references for the future development of agricultural antibiotics.