粪菌移植治疗帕金森病的研究进展

Advances in fecal microbiota transplantation for treatment of Parkinson’s disease

摘要:

帕金森病 (Parkinson’s disease，PD) 是中老年人群常见的神经退行性疾病。PD患者常在疾病早期出现胃肠道症状。多项研究证实，肠道菌群参与了PD的疾病过程。粪菌移植 (Fecal microbiota transplantation，FMT)作为一种有效的重建患者整体肠道菌群的方法，显示出了对PD的潜在治疗作用。文中着重围绕FMT治疗PD的基础和临床研究进行综述。

Abstract:

Parkinson’s disease (PD) is a common neurodegenerative disease in middle-aged and elderly people. Patients with PD often suffer from gastrointestinal symptoms in the early stage of the disease. Several studies have confirmed that gut microbiota is involved in the progress of PD. As one of the most effective ways to reconstruct the gut microbiota, fecal microbiota transplantation (FMT) has shown potential therapeutic effects on PD. This review summarizes the basic and clinical studies of FMT in the treatment of PD.