诱导多能干细胞向巨噬细胞分化研究进展

Induction and differentiation of induced pluripotent stem cells into macrophages: a review

摘要:

诱导多能干细胞 (Induced pluripotent stem cells，iPSCs) 是通过体细胞重编程得到类似胚胎干细胞特性的一种细胞类型。通过iPSCs的体外分化，可以了解巨噬细胞的进化历史和各种特性。iPSCs来源的巨噬细胞不仅是药物筛选的良好模型，也是进行免疫治疗的重要手段。本文综述了近年来iPSCs及其向巨噬细胞分化的相关研究进展、所面临的问题以及未来的发展方向。

Abstract:

Induced pluripotent stem cells (iPSCs) are a type of cells similar to embryonic stem cells but produced by reprogramed somatic cells. Through in vitro differentiation of iPSCs, we can interrogate the evolution history as well as the various characteristics of macrophages. iPSCs derived macrophages are not only a good model for drug screening, but also an important approach for immunotherapy. This review summarizes the advances, challenges, and future directions in the field of iPSCs-derived macrophages.