从蛋白质基因组学视角出发的精准肿瘤学

Precision oncology from a proteogenomics perspective

摘要:

癌症是一种机制复杂的异质性疾病，需要有针对性的精准医疗策略。精准医疗的发展离不开基因组学的飞速发展，但基因组学在分子表型分析中具有一定的局限性，蛋白质基因组学应运而生。蛋白质基因组学是蛋白质组学和基因组学的融合学科。文中描述了基因组学分析的局限性，强调了蛋白质基因组学的重要性，旨在从蛋白质基因组的视角重新了解精准肿瘤学。此外，还简要介绍了蛋白质基因组学在精准肿瘤学中的应用，对相关的公共数据项目进行了描述，最后，提出了现阶段需要克服的困难。

Abstract:

Cancer is a heterogeneous disease with complex mechanisms that requires targeted precision medicine strategies. The growth of precision medicine is indispensable from the rapid development of genomics. However, genomics has certain limitations in molecular phenotype analysis, proteogenomics thus arose at the right time. Proteogenomics is the merging of proteomics and genomics. This review describes the limitations of genomic analysis and highlights the importance of proteogenomics to re-understand precision oncology from a proteogenomic perspective. In addition, the application of proteogenomics in precision oncology is briefly introduced, the related public data projects are described, and finally, the challenges that need to be addressed at this stage are proposed.