肌肉因子对骨骼肌纤维类型转化的作用及机制研究进展

Progress and prospects of the effects and mechanisms of myokines in regulating fiber type transition of skeletal muscle

摘要:

骨骼肌纤维类型转化是极其复杂且重要的生理过程，影响骨骼肌肌肉功能和代谢水平，不仅受到外界环境变化的影响，还受内在生理机制的调控。因此深入探究肌纤维类型转化的生理过程对于治疗人类神经肌肉疾病以及提高家畜肉质具有重要意义。由骨骼肌分泌的细胞因子，即肌肉因子，对骨骼肌纤维类型转化具有重要作用，主要通过自分泌和旁分泌的形式作用于骨骼肌，参与骨骼肌内信号传导，调控肌纤维类型转化。本文介绍了各种骨骼肌纤维类型间的功能差异，并对影响不同骨骼肌纤维类型转化过程的肌肉因子及其调控肌纤维类型转化的作用及机制进行综述和展望，为改善家畜肉质和治疗骨骼肌相关疾病提供了理论依据。

Abstract:

The fiber type transition of skeletal muscle is an intricate and essential physiological process in the body, significantly influencing both the function and metabolism of skeletal muscle. This phenomenon is not only affected by external environmental changes but also intricately regulated by internal physiological mechanisms. Therefore, exploring the physiological process of muscle fiber type transition holds considerable significance for the treatment of human neuromuscular disorders and the improvement of meat quality in livestock and poultry. It has been discovered that the cytokines secreted by skeletal muscle, i.e., myokines, play a role in the fiber type transition of skeletal muscle. Myokines mainly act on skeletal muscle in autocrine and paracrine forms to participate in signal transduction and regulate the fiber type transition of skeletal muscle. This paper reviews the functional differences among various muscle fiber types, expounds the effects and mechanisms of myokines in regulating the transition processes of these fiber types, and prospects the future research directions in this field. This review is expected to provide theoretical support for enhancing the meat quality of livestock and poultry and treating skeletal muscle-related diseases.