RNA干扰生物农药的生物合成与载药递送研究进展

Research advances in the biosynthesis and delivery of RNAi-based biopesticides

摘要:

RNA干扰(RNA interference, RNAi)是真核生物中基于双链RNA (double-stranded RNA, dsRNA)介导同源mRNA降解的一种特异性转录后基因沉默机制。在探索与革新绿色生物农业的背景下，发展环保可靠的生物农药已成为植物病害防治领域的新态势。目前，RNAi生物农药作为一种新型农药，凭借强特异性、环境友好等优于传统化学农药的特性，成为当前的研究热点和优先发展的对象。本文综述了dsRNA的生物合成系统、维持dsRNA稳定的多种载药递送途径的相关研究进展，为国内相关领域研究工作提供了参考。

Abstract:

RNA interference (RNAi) is a specific post-transcriptional gene silencing mechanism in eukaryotes that mediates homologous mRNA degradation based on double-stranded RNA (dsRNA). Against the backdrop of exploring and innovating green bio-agriculture, the development of environmentally friendly and reliable biopesticides has become a new trend in plant disease control. At present, RNAi-based biopesticides, as a new type of pesticides, have become a current research hotspot and a priority of development due to their strong specificity and environmental friendliness that distinguish them from chemical pesticides. This paper reviews the biosynthesis system of dsRNA and various drug delivery routes for maintaining the stability of dsRNA, with the aim of providing references for domestic research in related fields.