抗酶解抗菌肽的研究进展

Research progress in anti-enzymatic antimicrobial peptides

摘要:

抗菌肽(antimicrobial peptides, AMPs)是机体先天免疫中的一类小分子多肽，作为机体防御的第一道防线，在自然界中广泛存在。AMPs具有多种生物学活性且不易产生耐药性，但天然AMPs容易被体内的各种消化酶降解。在AMPs中引入非天然氨基酸、化学修饰、合理规避酶切位点进行氨基酸重排、肽的环化、纳米肽设计等提高AMPs蛋白酶稳定的方法不断出现。本文重点综述了提高AMPs蛋白酶稳定性的各种方法，以期为此领域的研究提供参考。

Abstract:

Antimicrobial peptides (AMPs) are small molecular peptides widely existing in the innate immunity of organisms, serving as the first line of defense. Natural AMPs possess various biological activities and are difficult to develop drug resistance. However, they are easily broken down by digestive enzymes in the body. In recent years, increasing methods have been reported to enhance the stability of AMPs, including incorporation of unnatural amino acids, chemical modifications, strategic avoidance of enzyme cleavage sites, cyclization, and nano peptide design. This review summarizes the methods for improving the stability of AMPs against protease degradation, aiming to provide references for further research in this field.