微针递送技术在疫苗免疫中的研究进展

Research progress in microneedle-mediated vaccination

摘要:

接种疫苗是预防疾病、降低死亡率最有效的措施之一，微针递送能克服传统免疫方式本身存在的部分问题，实现疫苗的高效免疫，在传染病和癌症免疫治疗中应用前景广阔。本文对微针免疫原理、各类型微针疫苗制备和应用、微针免疫增强机制、提高微针免疫效果策略等方面的研究进行了综述和探讨，为微针在疫苗免疫方面的研究与应用提供了参考。

Abstract:

Vaccination is one of the most effective measures for disease prevention and mortality reduction. Microneedle delivery can overcome certain limitations of conventional immunization methods, enabling efficient vaccine administration and demonstrating broad application prospects in infectious disease and cancer immunotherapy. This article reviews and discusses the principles of microneedle-mediated vaccination, the preparation and application of various types of microneedle-mediated vaccines, the mechanisms of immune enhancement by microneedles, and strategies to improve their immunogenicity. It aims to provide a reference for future research and application of microneedles in vaccination.