Abstract:Biomanufacturing, as an emerging industry, is profoundly reshaping the global industrial landscape due to its green, low-carbon, efficient, and sustainable characteristics. Driven by artificial intelligence, this field urgently demands interdisciplinary applied talents proficient in both biological and computational sciences. In response, establishing the course Computational Biology to aligns with the national major development plans and cultivate the required talents is a significant measure. This paper elaborates on the urgency and practical significance of developing this course, as well as the challenges involved. Basing on the development direction of biomanufacturing, disciplinary trends, and students’ learning needs in Computational Biology, a development framework aimed at cultivating applied talents is proposed. Furthermore, the implementation plan for the course is detailed from three perspectives: designing the teaching contents, integrating diverse pedagogical approaches, and improving the teaching evaluation system. The implementation of this course will help to cultivate professionals skilled in applying computational biology tools to the biomanufacturing sector, while also providing valuable experience and reference for other universities offering similar courses.