菌源代谢物挖掘与膳食营养干预

Mining and dietary interventions of gut microbiota-derived metabolites

摘要:

肠道是一个复杂的共生系统，肠道菌群与宿主健康密切相关。肠道菌通过产生丰富的代谢物影响宿主的生理功能，这些代谢物作为信号分子和代谢反应的底物在宿主体内发挥作用。肠道菌群失调影响宿主体内菌源代谢物的丰度，通过破坏宿主靶点的信号转导进而影响宿主健康。此外，膳食营养组分也能够塑造肠道菌群，影响菌源代谢水平调控宿主代谢。本文综述了国内外研究成果，重点介绍了菌源代谢物的挖掘方法以及相关的膳食营养干预手段，展望了以菌源代谢物为靶点的代谢性疾病预防与治疗前景，为深入理解肠道菌群在调控宿主代谢中的作用提供了参考。

Abstract:

The intestine is a complex symbiotic system, and the gut microbiota is closely related to host health. Studies have indicated that the gut microbiota influences physiological functions of the host by producing a variety of metabolites, which act as signaling molecules and substrates for metabolic reactions in the host. Dysbiosis of the gut microbiota affects the abundance of gut microbiota-derived metabolites, thereby influencing host health by disrupting signal transduction in multiple organs. Additionally, dietary compounds can shape the gut microbiota, affecting gut microbiota-derived metabolite levels and regulating host metabolism. This article introduces the methods for mining gut microbiota-derived metabolites, reviews the roles of these metabolites in metabolic diseases and related dietary interventions. Which provides a perspective on the prevention and treatment of metabolic diseases by targeting these metabolites, enriching the knowledge on the role of gut microbiota in the regulation of host metabolism.