医美活性成分微生物合成研究进展

Advances in the microbial synthesis of active ingredients in cosmetics

摘要:

随着医美产业的蓬勃发展，使用功能性护肤产品成为主要趋势。医美产品功能的发挥，主要取决于其活性成分的功效。这些活性成分主要包括蛋白质和肽类、多糖类、酚酸类、萜烯类、维生素类、氨基酸类等，涉及修复、补水、美白、抗紫外和抗衰等功能。早年间这些活性成分主要通过生物提取和化学合成的方式获得。随着生物制造技术的发展，微生物合成医美活性成分已被广泛研究和应用。本文对通过微生物合成生物技术合成胶原蛋白、肽类、透明质酸、多酚类、萜烯类和维生素等天然产物的研究进行了总结，并对其合成途径、代谢调控以及未来的发展进行了综述，为后续微生物合成医美活性成分提供参考。

Abstract:

With the rapid development of the medical beauty industry, functional skin care products become increasingly popular. The functions of cosmetics mainly depend on the active ingredients, which are mainly proteins, peptides, polysaccharides, phenolic acids, terpenes, vitamins, and amino acids. These active ingredients endow cosmetics with skin repairing, moistening, whitening, UV protecting, and anti-aging effects. They are mainly obtained through biological extraction and chemical synthesis. In recent years, with the development of biomanufacturing, microbial synthesis of active ingredients in cosmetics has been widely studied and applied. This article reviews the research progresses in the production of natural products including collagens, peptides, hyaluronic acid, polyphenols, terpenes, and vitamins by microbial synthetic biotechnology. Moreover, this article highlighted the synthetic pathways, metabolic regulation, and prospects of the natural products, providing a reference for subsequent microbial synthesis of active ingredients in cosmetics.